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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cryobiopsy (transbronchial pulmonary-; TBLB TBLCB)

4
Last update : 06/03/2022
I - Interstitial/parenchymal lung disease

I.y Progression, acceleration or exacerbation of preexisting ILD/fibrosis

1
III - Pulmonary/alveolar./airway hemorrhage/bleeding

III.c Hemoptysis

2

III.h Major/massive hemoptysis

2

III.l Alveolar hemorrhage, localized (e.g. lobar)

1
V - Pleural and/or pericardial involvement

V.f Pneumothorax

2
XVI - Imaging

XVI.ab Imaging: Cavitating/cavitary lung nodule, mass or nodules (see also Iq, XIs, XIIi, XVIaa and XVIIp)

1

XVI.af Imaging: Lung cysts or bullae (see also XVI ah/bf)

1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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