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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Daclizumab
2
Last update :
04/05/2019
X - Systemic/Distant conditions, syndromes and reactions
X.a
DRES syndrome - DRESS-like reaction
1
X.f
Anaphylaxis-Anaphylactoid reaction (can be fatal)
1
X.k
Sarcoid-like granulomatosis (endo-/extrathoracic)
2
XI - Miscellaneous
XI.b
Chest pain (acute or subacute), lone or prominent
1
XI.n
Neutropenia, agranulocytosis (w/wo infection/sepsis)
1
XVII - Infections & related conditions
XVII.a
Respiratory tract infection incl. pneumonia
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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