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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Mogamulizumab
1
Last update :
25/02/2016
I - Interstitial/parenchymal lung disease
I.b
Pneumonitis (ILD)
-
X - Systemic/Distant conditions, syndromes and reactions
X.j
Myopathy-Myositis-Polymyositis (see also under Xba)
1
XII - Cardiovascular involvement / toxicity
XII.d
Myocarditis (can be fulminant)
1
XV - Pathology
XV.ca
Path: Myocarditis
1
XVII - Infections & related conditions
XVII.a
Respiratory tract infection incl. pneumonia
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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