The Drug-Induced Respiratory Disease Website and App

Methanol (oral, topical/dermal, systemic)

Accidental or with suicidal intent. Can be present in household and hospital hand sanitizers (PMID 29987197, 29987197). Early identification, management and administration of ethanol anD/or antidotes are indicated.

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.e

ARDS - Acute lung injury

XLI.p

Acute respiratory or cardiopulmonary failure

XLVIII - Neuromuscular / CNS involvement - Disordered breathing (during sleep)

XLVIII.i

Respiratory arrest - Apnea

L - Miscellaneous

L.e

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea