The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

The first PIE case from the West has been reported by canadian investigators in 2016 (PMID 27445539)

Publications

Saint-Pierre MD, Moran-Mendoza O

Acetaminophen Use: An Unusual Cause of Drug-Induced Pulmonary Eosinophilia.

Canadian respiratory journal 2016;2016;4287270 — 2016 — 4287270

Kondo K, Inoue Y, Hamada H, Yokoyama A, Kohno N, Hiwada K

Acetaminophen-induced eosinophilic pneumonia.

Chest 1993 Jul;104;291-2 — 1993 Jul — 291-2