The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Cekmen N, Cesur M, Cetinbas R, Bedel P, Erdemli O

Acute pulmonary edema due to rosiglitazone use in a patient with diabetes mellitus.

Journal of intensive care medicine 2006 Jan-Feb;21;47-50 — 2006 Jan-Feb — 47-50

Kermani A, Garg A

Thiazolidinedione-associated congestive heart failure and pulmonary edema.

Mayo Clinic proceedings 2003 Sep;78;1088-91 — 2003 Sep — 1088-91