The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD)

Differential in ALS includes aspiration pneumonia.

Publications

Saitoh Y, Aoshima Y, Mukai T, Abe H, Ariga H, Mori-Yoshimura M, Okamoto T, Takahashi Y

Riluzole-induced interstitial lung disease is a rare and potentially life-threatening adverse event successfully treated with high-dose steroid therapy: Case reports and review of the literature.

Journal of the neurological sciences 2019 Dec 27;410;116650 — 2019 Dec 27 — 116650

Takeshima S, Neshige S, Himeno T, Takamatsu K, Shimoe Y, Kuriyama M

[Riluzole-induced interstitial pneumonia in a case with amyotrophic lateral sclerosis].

Rinsho shinkeigaku = Clinical neurology 2015;55;840-3 — 2015 — 840-3

Kakuta T, Hirata H, Soda S, Shiobara T, Watanabe M, Tatewaki M, Fukushima F, Chibana K, Sugiyama K, Arima M, Koichi H, Fukuda T, Fukushima Y

Riluzole-induced lung injury in two patients with amyotrophic lateral sclerosis.

Internal medicine (Tokyo, Japan) 2012;51;1903-7 — 2012 — 1903-7

Theunissen T, Coddens J, Foubert L, Cammu G, Degrieck I, Deloof T

Intraoperative severity assessment of coronary artery stenosis in patients at risk: the role of transesophageal echocardiography.

Anesthesia and analgesia 2006 Feb;102;366-8 — 2006 Feb — 366-8

Borderías-Clau L, Garrapiz-López J, Val-Adán P, Tordesillas-Lía C, Alcacera-López A, Bru-Martín JL

[Strong suspicion of lung toxicity due to riluzole].

Archivos de bronconeumologia 2006 Jan;42;42-4 — 2006 Jan — 42-4

Cassiman D, Thomeer M, Verbeken E, Robberecht W

Hypersensitivity pneumonitis possibly caused by riluzole therapy in ALS.

Neurology 2003 Oct 28;61;1150-1 — 2003 Oct 28 — 1150-1