The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.a

Angioedema (may cause UAO, asphyxia and death)

Publications

Burd M, McPheeters C, Scherrer LA

Orolingual Angioedema After Tissue Plasminogen Activator Administration in Patients Taking Angiotensin-Converting Enzyme Inhibitors.

Advanced emergency nursing journal 2019 Jul/Sep;41;204-214 — 2019 Jul/Sep — 204-214

Rathbun KM

Angioedema after thrombolysis with tissue plasminogen activator: an airway emergency.

Oxford medical case reports 2019 Jan;2019;omy112 — 2019 Jan — omy112

Khalid M, Kanaa M, Alkawaleet Y, Ayub MT

Angioedema: A Life-threatening Complication of Tissue Plasminogen Activator.

Cureus 2018 Mar 29;10;e2392 — 2018 Mar 29 — e2392