The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary arterial hypertension
Publications
Post-marketing safety of lorlatinib: a real-world study based on the FDA adverse event reporting system.
Frontiers in pharmacology 2024;15;1385036 — 2024 — 1385036
Chabrol A, Mayenga M, Hamid AM, Friard S, Salvator H, Doubre H, Fraboulet S, Metivier AC, Catherinot E, Rivaud E, Chaumais MC, Montani D, Couderc LJ, Tcherakian C
Lorlatinib - Induced pulmonary arterial hypertension.
Lung cancer (Amsterdam, Netherlands) 2018 06;120;60-61 — 2018 06 — 60-61