The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Publications

Ergin AB, Fong N, Daw HA

Rituximab-induced bronchiolitis obliterans organizing pneumonia.

Case reports in medicine 2012;2012;680431 — 2012 — 680431

Bauer PR, Zent CS, Aubry MC, Ryu JH

Recurrent fevers, cough, and pulmonary opacities in a middle-aged man.

Chest 2010 Jun;137;1465-9 — 2010 Jun — 1465-9

Bitzan M, Ouahed JD, Carpineta L, Bernard C, Bell LE

Cryptogenic organizing pneumonia after rituximab therapy for presumed post-kidney transplant lymphoproliferative disease.

Pediatric nephrology (Berlin, Germany) 2010 Jun;25;1163-7 — 2010 Jun — 1163-7

Bitzan M, Anselmo M, Carpineta L

Rituximab (B-cell depleting antibody) associated lung injury (RALI): a pediatric case and systematic review of the literature.

Pediatric pulmonology 2009 Sep;44;922-34 — 2009 Sep — 922-34

Lioté H, Lioté F, Séroussi B, Mayaud C, Cadranel J

Rituximab-induced lung disease: A systematic literature review.

The European respiratory journal 2010 Mar;35;681-7 — 2010 Mar — 681-7

Soubrier M, Jeannin G, Kemeny JL, Tournadre A, Caillot N, Caillaud D, Dubost JJ

Organizing pneumonia after rituximab therapy: Two cases.

Joint, bone, spine : revue du rhumatisme 2008 May;75;362-5 — 2008 May — 362-5

Biehn SE, Kirk D, Rivera MP, Martinez AE, Khandani AH, Orlowski RZ

Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.

Hematological oncology 2006 Dec;24;234-7 — 2006 Dec — 234-7