The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Annoh Gordon R, Silhan L

A case report of phenytoin-induced eosinophilic pneumonia.

Respiratory medicine case reports. 2019;28:100922

Dixit R, Dixit K, Nuwal P, Banerjee A, Sharma S, Dave L

Diphenylhydantoin (phenytoin)-induced chronic pulmonary disease.

Lung India : official organ of Indian Chest Society. 2009;26(4):155-8

Müller NL, White DA, Jiang H, Gemma A

Diagnosis and management of drug-associated interstitial lung disease.

British journal of cancer. 2004;91 Suppl 2(Suppl 2):S24-30

Lazoglu AH, Boglioli LR, Dorsett B, Macris NT

Phenytoin-related immunodeficiency associated with Loeffler's syndrome.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 1995;74(6):479-82

Yermakov VM, Hitti IF, Sutton AL

Necrotizing vasculitis associated with diphenylhydantoin: two fatal cases.

Human pathology. 1983;14(2):182-4

Mahatma M, Haponik EF, Nelson S, Lopez A, Summer WR

Phenytoin-induced acute respiratory failure with pulmonary eosinophilia.

The American journal of medicine. 1989;87(1):93-4