The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea
Publications
Severe non-anion gap metabolic acidosis induced by topiramate: a case report.
The Journal of emergency medicine 2010 May;38;494-6 — 2010 May — 494-6
Hyperchloremic, normal anion-gap, metabolic acidosis due to topiramate.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2008 Aug 01;65;1430-4 — 2008 Aug 01 — 1430-4
Migraine and topiramate induced dyspnea.
Headache 2007 Nov-Dec;47;1453-5 — 2007 Nov-Dec — 1453-5