The Drug-Induced Respiratory Disease Website and App

Forceful inspiration against a closed glottis or airway

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.f

Negative pressure pulmonary hemorrhage (NPPH)

Publications

Mendonça MC, Abreu JB, Gama K

Diffuse Alveolar Hemorrhage After Orotracheal Extubation Probably Induced by Sevoflurane Inhalation.

Archivos de bronconeumologia. 2021

Saeed AI, Quintana C, McGuire FR, Barker JA

Delayed presentation: negative pressure pulmonary hemorrhage.

Journal of clinical anesthesia. 2012;24(6):490-3

Broccard AF, Liaudet L, Aubert JD, Schnyder P, Schaller MD

Negative pressure post-tracheal extubation alveolar hemorrhage.

Anesthesia and analgesia. 2001;92(1):273-5