The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cardiovascular collapse - Cardiogenic shock - Hypotension
Publications
Hydrochlorothiazide-induced systemic capillary leak.
The American journal of emergency medicine. 2020;38(6):1299.e1-1299.e2
Severe allergic reaction to hydrochlorothiazide mimicking septic shock.
Pharmacotherapy. 2009;29(3):357-61
Hydrochlorothiazide-associated noncardiogenic pulmonary oedema and shock: a case report and review of the literature.
Acta cardiologica. 2007;62(2):215-20
[Hydrochlorothiazide-induced lung edema with shock].
Schweizerische medizinische Wochenschrift. 1988;118(4):139-42
Pulmonary oedema with shock induced by hydrochlorothiazide: a rare side effect mimicking myocardial infarction.
British heart journal. 1990;63(3):186