The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Bugay V, Gregory SR, Belanger-Coast MG, Zhao R, Brenner R

Effects of Sublethal Organophosphate Toxicity and Anti-cholinergics on Electroencephalogram and Respiratory Mechanics in Mice.

Frontiers in neuroscience 2022;16;866899 — 2022 — 866899

Shaikh S, Khaskheli MS, Meraj M, Raza H

Effect of Organophasphate poisoning among patients reporting at a tertiary healthcare facility of Sindh Pakistan.

Pakistan journal of medical sciences 2018 May-Jun;34;719-723 — 2018 May-Jun — 719-723

Vale A

Organophosphorus insecticide poisoning.

BMJ clinical evidence 2015 Nov 30;2015; — 2015 Nov 30

Hulse EJ, Davies JO, Simpson AJ, Sciuto AM, Eddleston M

Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care.

American journal of respiratory and critical care medicine 2014 Dec 15;190;1342-54 — 2014 Dec 15 — 1342-54

Carey JL, Dunn C, Gaspari RJ

Central respiratory failure during acute organophosphate poisoning.

Respiratory physiology & neurobiology 2013 Nov 01;189;403-10 — 2013 Nov 01 — 403-10