The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Methemoglobinemia
Publications
Zopiclone induced methemoglobinemia and hemolytic anemia.
International journal of clinical pharmacology and therapeutics 2014 May;52;402-6 — 2014 May — 402-6
Two cases of methemoglobinemia following zopiclone ingestion.
Clinical toxicology (Philadelphia, Pa.) 2008 Feb;46;167-70 — 2008 Feb — 167-70