The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.k

Airway fire/explosion

Sevoflurane may interact with baralyme cartridge in the ventilator

Publications

Castro BA, Freedman LA, Craig WL, Lynch C 3rd

Explosion within an anesthesia machine: Baralyme, high fresh gas flows and sevoflurane concentration.

Anesthesiology. 2004;101(2):537-9

Wu J, Previte JP, Adler E, Myers T, Ball J, Gunter JB

Spontaneous ignition, explosion, and fire with sevoflurane and barium hydroxide lime.

Anesthesiology. 2004;101(2):534-7

Fatheree RS, Leighton BL

Acute respiratory distress syndrome after an exothermic Baralyme-sevoflurane reaction.

Anesthesiology. 2004;101(2):531-3