The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIV.b

Sulfhemoglobinemia

Publications

Moritz BW, Chouairi F, Tosh A, Toffaletti JG, Rackley CR

A 36-Year-Old Woman With Intermittent Cyanosis.

Chest 2024 Aug;166;e29-e33 — 2024 Aug — e29-e33

Soderstrom M, Foster DV, Hamidi ZS, Anderson JT

Sulfhemoglobinemia in a 53-Year-Old With a History of Phenazopyridine Misuse.

Cureus 2023 Jun;15;e40944 — 2023 Jun — e40944

Kermani TA, Pislaru SV, Osborn TG

Acrocyanosis from phenazopyridine-induced sulfhemoglobinemia mistaken for Raynaud phenomenon.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2009 Apr;15;127-9 — 2009 Apr — 127-9

Gopalachar AS, Bowie VL, Bharadwaj P

Phenazopyridine-induced sulfhemoglobinemia.

The Annals of pharmacotherapy 2005 Jun;39;1128-30 — 2005 Jun — 1128-30

Halvorsen SM, Dull WL

Phenazopyridine-induced sulfhemoglobinemia: inadvertent rechallenge.

The American journal of medicine 1991 Sep;91;315-7 — 1991 Sep — 315-7