The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Alveolar hemorrhage, diffuse (ANCA-positive/-related)
Publications
Propylthiouracil-induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody.
The European respiratory journal 1997 Jun;10;1405-7 — 1997 Jun — 1405-7
Goodpasture-like syndrome associated with anti-myeloperoxidase antibodies following penicillamine treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995 Oct;10;1925-8 — 1995 Oct — 1925-8