The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.s

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

Publications

Hacking S, Uppal NN, Khan N, Ionescu M, Bijol V

Systemic p-ANCA vasculitis with fatal outcome, arising in the setting of methimazole use.

Clinical nephrology. Case studies. 2019;7:23-26

Shikha D, Harris J, Resta C, Park P

Antineutrophilic Cytoplasmic Antibody Positive Vasculitis Associated with Methimazole Use.

Case reports in endocrinology. 2015;2015:530319

Yasude T, Kishida D, Tazawa K, Matsuda M, Ishii W, Yazaki M, Ikeda S

ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole.

Internal medicine (Tokyo, Japan). 2012;51(22):3177-80

Bilge NS, Kaşifoğlu T, Korkmaz C

PTU-induced ANCA-positive vasculitis: an innocent or a life-threatening adverse effect?

Rheumatology international. 2013;33(1):117-20

Ahmed K, Rao S, Simha V

Antineutrophil cytoplasmic antibody-positive vasculitis in a patient with graves disease: cross-reaction between propylthiouracil and methimazole.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2010;16(3):449-51

Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M

Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides.

Arthritis research & therapy. 2005;7(5):R1072-81