The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Popio?ek I, Piotrowicz-Wójcik K, Porebski G

Hypersensitivity Reactions in Serious Adverse Events Reported for Paracetamol in the EudraVigilance Database, 2007?2018.

Pharmacy (Basel, Switzerland) 2019 Jan 17;7; — 2019 Jan 17

Renaudin JM, Beaudouin E, Ponvert C, Demoly P, Moneret-Vautrin DA

Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.

Allergy 2013 Jul;68;929-37 — 2013 Jul — 929-37

Couto M, Gaspar A, Morais-Almeida M

Selective anaphylaxis to paracetamol in a child.

European annals of allergy and clinical immunology 2012 Aug;44;163-6 — 2012 Aug — 163-6

Schwarz N, Ham Pong A

Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1996 Dec;77;473-4 — 1996 Dec — 473-4