The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIII.a

Bronchospasm - Wheezing - Asthma

Bronchospasm restricted to aspirin/NSAID-intolerant patients (PMID 7560658). Use of acetaminophen in asthmatic children regarded as safe (PMID 27532828)

Publications

Kivity S, Pawlik I, Katz Y

Acetaminophen hypersensitivity.

Allergy 1999 Feb;54;187-8 — 1999 Feb — 187-8

Schwarz N, Ham Pong A

Acetaminophen anaphylaxis with aspirin and sodium salicylate sensitivity: a case report.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 1996 Dec;77;473-4 — 1996 Dec — 473-4

Settipane RA, Schrank PJ, Simon RA, Mathison DA, Christiansen SC, Stevenson DD

Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects.

The Journal of allergy and clinical immunology 1995 Oct;96;480-5 — 1995 Oct — 480-5

Fisher CJ, Albertson TE, Foulke GE

Salicylate-induced pulmonary edema: clinical characteristics in children.

The American journal of emergency medicine 1985 Jan;3;33-7 — 1985 Jan — 33-7