The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Upper airway obstruction other than angioedema or hematoma
Insoluble, needle-shaped abrasive oxalate crystals can be causative (PMID: 30262249)
Publications
Mucosal Injury From Calcium Oxalate Crystals Resembling Anaphylaxis and Angioedema.
The Journal of emergency medicine 2018 Nov;55;666-669 — 2018 Nov — 666-669
[Herbal medicines and severe adverse effects: uvular angioedema caused by Echballium elaterium].
Revista medica de Chile 2002 Dec;130;1407-10 — 2002 Dec — 1407-10