Back to drug

The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.b

Pulmonary arterial hypertension

Publications

Sato K, Ohira H, Horinouchi T, Nakaya T, Mazaki Y, Sugimoto A, Watanabe T, Tsujino I, Nishimura M

Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis: A case report and experimental investigation.

Respiratory medicine case reports. 2019;26:265-269

Misumi K, Ogo T, Ueda J, Tsuji A, Fukui S, Konagai N, Asano R, Yasuda S

Development of Pulmonary Arterial Hypertension in a Patient Treated with Qing-Dai (Chinese Herbal Medicine).

Internal medicine (Tokyo, Japan). 2019;58(3):395-399

Nishio M, Hirooka K, Doi Y

Chinese herbal drug natural indigo may cause pulmonary artery hypertension.

European heart journal. 2016;37(25):1992

Sakurai Y, Tanabe N, Sekine A, Nishimura R, Jujo T, Kawasaki T, Sugiura T, Sakao S, Kasahara Y, Tatsumi K

Spontaneously remitted pulmonary arterial hypertension associated with the herbal medicine "bofutsushosan".

Internal medicine (Tokyo, Japan). 2013;52(13):1499-502

Györik S, Stricker H

Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy.

Swiss medical weekly. 2009;139(13-14):210-1