The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Arts J, D'Haens G, Zeegers M, Van Assche G, Hiele M, D'Hoore A, Penninckx F, Vermeire S, Rutgeerts P

Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitis.

Inflammatory bowel diseases. 2004;10(2):73-8

Ebo DG, Piel GC, Conraads V, Stevens WJ

IgE-mediated anaphylaxis after first intravenous infusion of cyclosporine.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2001;87(3):243-5

Kuiper RA, Malingré MM, Beijnen JH, Schellens JH

Cyclosporine-induced anaphylaxis.

The Annals of pharmacotherapy. 2000;34(7-8):858-61