The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Fernández-Delgado E, Egea-Guerrero JJ, Freire-Aragón MD, Rivera-Fernández V, Durán-Martínez P

[Severe respiratory failure and neuromuscular blockade after administration of colimycin].

Medicina intensiva. 2015;39(7):448-9

Shrestha A, Soriano SM, Song M, Chihara S

Intravenous colistin-induced acute respiratory failure: A case report and a review of literature.

International journal of critical illness and injury science. 2014;4(3):266-70

Fernández AB, Pérez M, Soto L

Sudden respiratory muscle paralysis and apnea in a patient infected with multidrug-resistant Pseudomonas aeruginosa treated with intravenous colistin.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2013;17(5):e357

Wunsch H, Moitra VK, Patel M, Dzierba AL

Polymyxin use associated with respiratory arrest.

Chest. 2012;141(2):515-517

PERKINS RL

APNEA WITH INTRAMUSCULAR COLISTIN THERAPY.

JAMA. 1964;190:421-4

Parisi AF, Kaplan MH

Apnea during treatment with sodium colistimethate.

JAMA. 1965;194(3):298-9