The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Travis WD, Kalafer ME, Robin HS, Luibel FJ

Hypersensitivity pneumonitis and pulmonary vasculitis with eosinophilia in a patient taking an L-tryptophan preparation.

Annals of internal medicine. 1990;112(4):301-3

Uchida T, White JJ Jr, Neuwirth H

DNA minisatellites demonstrate somatic DNA changes in most human bladder cancers.

Cytogenetics and cell genetics. 1990;53(1):61-3

Williamson MR, Eidson M, Rosenberg RD, Williamson SL

Eosinophilia-myalgia syndrome: findings on chest radiographs in 18 patients.

Radiology. 1991;180(3):849-52

Campagna AC, Blanc PD, Criswell LA, Clarke D, Sack KE, Gold WM, Golden JA

Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion.

Chest. 1992;101(5):1274-81