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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
VIII.af
Oromandibular dystonia
See also under IXk
Last update :
01/01/1970
Causative drugs
1
Capecitabine
I.m
I - Interstitial/parenchymal lung disease
I.m - ILD with a granulomatous component
VII.a
VII - Mediastinal involvement
VII.a - Lymphadenopathy (intrathoracic)
VIII.af
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.af - Oromandibular dystonia
X.k
X - Systemic/Distant conditions, syndromes and reactions
X.k - Sarcoid-like granulomatosis (endo-/extrathoracic)
XI.b
XI - Miscellaneous
XI.b - Chest pain (acute or subacute), lone or prominent
XII.d
XII - Cardiovascular involvement / toxicity
XII.d - Myocarditis (can be fulminant)
XII.g
XII - Cardiovascular involvement / toxicity
XII.g - Coronary artery disease (acute) - Myocardial ischemia/infarction
XII.af
XII - Cardiovascular involvement / toxicity
XII.af - Coronary vasospasm - Vasospastic angina
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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