Pneumotox » Drug » Niflumic acid » I.c - Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Niflumic acid

Evidence limited: Breton JL et al. Eosinophilic pneumonia induced by niflumic acid. Eur Respir J 1998. 12 (Suppl 28): 345s

Last update : 01/08/2019

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment