Pneumotox » Drug » Procainamide

Procainamide

4

Last update : 21/10/2012

I.b Pneumonitis (ILD)

1

V.a Pleural effusion (uni- or bilateral) (May commpany ILDs)

1

V.c Pleural thickening

2

V.d Pleural/pericardial effusion, ANA positive (DI lupus)

2

V.i Pleuritis (can cause chest pain)

2

VI.a Pulmonary embolism - Venous thrombosis/thromboembolism

1

X.b Antiphospholipid antibodies w/wo the APL syndrome

1

X.d Lupus - Lupus syndrome (see also Vd)

2

X.y Subclinical ANA positivity

1

XI.n Neutropenia, agranulocytosis (w/wo infection/sepsis)

1

XII.c Pericardial effusion (w/wo tamponade)

1

XII.k Constrictive pericarditis - Pericardial thickening

1

XII.p QTc prolongation

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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