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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
XV.bz
Path: Hydrophilic polymer emboli
Last update :
01/01/1970
Causative drugs
1
Catheter coating
V.a
V - Pleural and/or pericardial involvement
V.a - Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
VI.g
VI - Pulmonary vasculopathies
VI.g - Foreign body pulmonary vasculopathy (Excipient lung disease)
X.q
X - Systemic/Distant conditions, syndromes and reactions
X.q - Systemic inflammatory response
X.s
X - Systemic/Distant conditions, syndromes and reactions
X.s - Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive
XV.q
XV - Pathology
XV.q - Path: Foreign body deposits/granulomatous reaction
XV.ag
XV - Pathology
XV.ag - Path: Foreign body embolism, microangiopathy, vasculopathy
XV.bz
XV - Pathology
XV.bz - Path: Hydrophilic polymer emboli
XVI.w
XVI - Imaging
XVI.w - Imaging: Lung nodule or nodules
XVI.ab
XVI - Imaging
XVI.ab - Imaging: Cavitating/cavitary lung nodule, mass or nodules (see also Iq, XIs, XIIi, XVIaa and XVIIp)
XVI.an
XVI - Imaging
XVI.an - Imaging: Pleural effusion
1
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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