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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
XI.q
Lung compression from ascites
Can cause bibasilar plate-like atelectasis
Last update :
01/01/1970
Causative drugs
1
Gonadotropin
II.a
II - Pulmonary edema - Acute lung injury - ARDS
II.a - Pulmonary edema, noncardiogenic (NCPE)
II.b
II - Pulmonary edema - Acute lung injury - ARDS
II.b - ARDS - Acute lung injury
V.a
V - Pleural and/or pericardial involvement
V.a - Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
V.g
V - Pleural and/or pericardial involvement
V.g - Effusions of the ovarian hyperstimulation syndrome (OHSS)
V.i
V - Pleural and/or pericardial involvement
V.i - Pleuritis (can cause chest pain)
X.f
X - Systemic/Distant conditions, syndromes and reactions
X.f - Anaphylaxis-Anaphylactoid reaction (can be fatal)
X.r
X - Systemic/Distant conditions, syndromes and reactions
X.r - Fluid retention
XI.q
XI - Miscellaneous
XI.q - Lung compression from ascites
2
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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