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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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  • Drugs
  • Patterns

Alkylating agents

5

I.g Pulmonary fibrosis

3
Last update : 03/08/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Chemotherapy, antineoplastic
5
Cyclophosphamide
4
Nitrosoureas (suffixes '-NU', '-mustine')
4

Publications

Pulmonary fibrosis induced by cyclophosphamide.
The Annals of pharmacotherapy 2001;35;894-7 2001
Lung toxicity associated with cyclophosphamide use. Two distinct patterns.
American journal of respiratory and critical care medicine 1996 Dec;154;1851-6 1996 Dec

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