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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Fingolimod

1

XII.s Heart block (bundle branch- or AV-)

1
Last update : 19/06/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

AV block II in a toddler after ingestion of a single tablet fingolimod.
Clinical toxicology (Philadelphia, Pa.) 2014 Jul;52;644 2014 Jul
Overview and safety of fingolimod hydrochloride use in patients with multiple sclerosis.
Expert opinion on drug safety 2014 Jul;13;989-98 2014 Jul

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