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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Carfilzomib
1
XII.ai
Cardiotoxicity
1
Last update :
20/10/2016
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Cardiotoxicity associated with carfilzomib: systematic review and meta-analysis.
Carfilzomib and the cardiorenal system in myeloma: an endothelial effect?