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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Carfilzomib

1

VI.b Pulmonary arterial hypertension

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Last update : 07/12/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Carfilzomib-associated pulmonary arterial hypertension in multiple myeloma.
Pulmonary circulation 2021;11;20458940211049300 2021
Case series discussion of cardiac and vascular events following carfilzomib treatment: possible mechanism, screening, and monitoring.
BMC cancer 2014 Dec 04;14;915 2014 Dec 04

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