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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Diclofenac

2

IV.a Bronchospasm - Wheezing - Asthma

2
Last update : 22/10/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Nonsteroidal anti-inflammatory drugs (NSAIDs)
5

Publications

Spontaneous reporting of adverse drug reactions to non-steroidal anti-inflammatory drugs. A report from the Spanish System of Pharmacovigilance, including an early analysis of topical and enteric-coated formulations.
European journal of clinical pharmacology 1994;47;297-303 1994
Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen.
British medical journal 1977 Jul 23;2;231-2 1977 Jul 23

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