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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Status post-lung transplantation

4

XV.ap Path: Pleuroparenchymal fibrosis/fibroelastosis (PPFE)

2
Last update : 28/04/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
MTOR inhibitors
5

Publications

Pleuroparenchymal fibroelastosis as a series of airway complications associated with chronic graft-versus-host disease following allogeneic bone marrow transplantation.
Internal medicine (Tokyo, Japan) 2014;53;43-6 2014
Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013 Mar;26;350-6 2013 Mar

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