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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Gabapentin

2

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

2
Last update : 24/02/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Gabapentin and risk of severe respiratory depression.
Drug and therapeutics bulletin 2018 Jan;56;3-4 2018 Jan
Pattern of perioperative gabapentinoid use and risk for postoperative naloxone administration.
British journal of anaesthesia 2018 Apr;120;798-806 2018 Apr
Severe respiratory depression associated with perioperative opioid-sparing gabapentin use.
Anaesthesia and intensive care 2014 Jan;42;136-7 2014 Jan
[Gabapentin-induced central hypoventilation].
Medicina clinica 2007 Apr 07;128;519 2007 Apr 07
Recurrent hypoventilation and respiratory failure during gabapentin therapy.
Journal of the American Geriatrics Society 2001 Apr;49;498 2001 Apr

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