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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Gabapentin
2
IX.d
Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
2
Last update :
24/02/2018
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Gabapentin and risk of severe respiratory depression.
Pattern of perioperative gabapentinoid use and risk for postoperative naloxone administration.
Severe respiratory depression associated with perioperative opioid-sparing gabapentin use.
[Gabapentin-induced central hypoventilation].
Recurrent hypoventilation and respiratory failure during gabapentin therapy.