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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ethylene glycol

5

XI.d Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

5
Last update : 22/03/2022
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Antifreeze
1

Publications

Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review.
Clinical toxicology (Philadelphia, Pa.) 2022 Jul;60;784-797 2022 Jul
Lactate gap as a tool in identifying ethylene glycol poisoning.
BMJ case reports 2018 Mar 09;2018; 2018 Mar 09
Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.
Case reports in nephrology 2017;2017;9529028 2017
Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.
The New England journal of medicine 2015 Jan 29;372;465-73 2015 Jan 29
Case 38-1979: Ethylene glycol poisoning.
The New England journal of medicine 1980 Feb 21;302;466 1980 Feb 21

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