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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrous oxide (N2O)

1

VIII.c Upper airway obstruction other than angioedema or hematoma

1
Last update : 07/10/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Inhalants (volatile substances)
5
Inhaled anesthetic agents
3

Publications

Upper aerodigestive tract frostbite from inhalation of automotive nitrous oxide.
Ear, nose, & throat journal 2018 Sep;97;E13-E14 2018 Sep
Life-threatening airway obstruction from nitrous oxide induced frostbite of the oral cavity.
Anaesthesia and intensive care 1996 Dec;24;717-20 1996 Dec

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