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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Nitrous oxide (N2O)

1

VII.h Pneumomediastinum

1
Last update : 25/09/2015
 
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Diagnosing DIRD
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Inhalants (volatile substances)
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Inhaled anesthetic agents
3

Publications

Pneumomediastinum and pneumorrhachis from recreational nitrous oxide inhalation: no laughing matter.
Thorax 2018 Feb;73;195-196 2018 Feb
Recreational nitrous oxide inhalation as a rare cause of spontaneous pneumomediastinum.
BMJ case reports 2015 Sep 21;2015; 2015 Sep 21

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