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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Nitrous oxide (N2O)
1
VII.h
Pneumomediastinum
1
Last update :
25/09/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Inhalants (volatile substances)
Inhaled anesthetic agents
Publications
Pneumomediastinum and pneumorrhachis from recreational nitrous oxide inhalation: no laughing matter.
Recreational nitrous oxide inhalation as a rare cause of spontaneous pneumomediastinum.