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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Adenosine

2

IV.f Severe or catastrophic bronchospasm or asthma attack (can be fatal)

1
Last update : 29/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Adenosine-induced severe bronchospasm in a patient without pulmonary disease.
The American journal of emergency medicine 2012 Nov;30;2082.e3-5 2012 Nov
Intraoperative bronchospasm after intravenous adenosine during general anesthesia.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 2004 Dec;42;237-40 2004 Dec
Intraoperative bronchospasm caused by adenosine.
Anesthesiology 1993 Nov;79;1132-5 1993 Nov

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