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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dapsone (diaminophenylsulfone)

4

XIV.a Methemoglobinemia

3
Last update : 12/02/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Pyrimethamine-dapsone
1

Publications

Dapsone-Induced Methemoglobinemia in a Woman With Multiple Myeloma Without Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency.
Cureus 2024 Jun;16;e63249 2024 Jun
Detection of methaemoglobinaemia in a COVID-19 patient on dapsone.
BMJ case reports 2024 Jan 09;17; 2024 Jan 09
A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient.
Cureus 2023 Oct;15;e46690 2023 Oct
Methemoglobinemia With Dapsone Prophylaxis in a Patient With Minimal Change Disease.
Cureus 2022 Jun;14;e26393 2022 Jun
Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia.
CEN case reports 2021 Aug;10;336-340 2021 Aug
A case of dapsone-induced methaemoglobinaemia.
Clinical medicine (London, England) 2020 Sep;20;519-521 2020 Sep
A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.
Acta dermatovenerologica Croatica : ADC 2020 Dec;28;249-250 2020 Dec
[Methemoglobinemia caused by dapsone. Report of one case].
Revista medica de Chile 2020 Dec;148;1838-1843 2020 Dec
A case of DAPSONE INDUCED METHEMOGLOBINEMIA.
Journal of pharmaceutical policy and practice 2019;12;22 2019
Dapsone-induced Methemoglobinemia in a Patient of Leprosy.
Indian journal of dermatology 2015;60;108 2015
Dapsone-induced methemoglobinemia in renal transplant recipients: more prevalent than previously thought.
Transplant infectious disease : an official journal of the Transplantation Society 2014 Feb;16;37-43 2014 Feb
Symptomatic-low grade methemoglobinemia because of dapsone: a multiple hit hypothesis.
American journal of therapeutics 2013;20;e729-32 2013
Dapsone-induced methemoglobinemia: a primer for clinicians.
The Annals of pharmacotherapy 2011 Sep;45;1103-15 2011 Sep
Case records of the Massachusetts General Hospital: Case 7-2011: a 52-year-old man with upper respiratory symptoms and low oxygen saturation levels.
The New England journal of medicine 2011 Mar 10;364;957-66 2011 Mar 10
Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure.
Journal of medical toxicology : official journal of the American College of Medical Toxicology 2011 Jun;7;139-46 2011 Jun
Dapsone-induced methemoglobinemia: a dose-related occurrence?
Cancer 2011 Aug 01;117;3485-92 2011 Aug 01
Dyspnea in a lung transplant recipient.
Respiratory care 2010 May;55;626-9 2010 May
Pathophysiologic mechanisms, diagnosis, and management of dapsone-induced methemoglobinemia.
The Journal of the American Osteopathic Association 2010 Jan;110;16-20 2010 Jan
Dapsone-induced hemolytic anemia in lung allograft recipients.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2008 Nov;27;1198-202 2008 Nov
Dapsone induced methemoglobinemia : Intermittent vs continuous intravenous methylene blue therapy.
Indian journal of pediatrics 2008 Mar;75;245-7 2008 Mar
Methemoglobinemia associated with dapsone therapy in a child with pneumonia and chronic immune thrombocytopenic purpura.
Journal of pediatric hematology/oncology 2006 Jun;28;395-8 2006 Jun
Presentation of dapsone-induced methemoglobinemia in a patient status post small bowel transplant.
Journal of clinical anesthesia 2005 Nov;17;568-70 2005 Nov
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.
Medicine 2004 Sep;83;265-273 2004 Sep
[Respiratory insufficiency caused by dapsone-induced methemoglobinemia].
Ugeskrift for laeger 2001 Jan 01;163;39-40 2001 Jan 01
Dapsone-induced methemoglobinemia in pediatric oncology patients: case examples.
Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 2001;18;224-8 2001
Blue and breathless.
Hospital medicine (London, England : 1998) 1999 Jul;60;530 1999 Jul
Acute dapsone intoxication: a pediatric case report.
Pediatric emergency care 1997 Apr;13;127-9 1997 Apr
Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and clindamycin-primaquine. ACTG 108 Study Group.
Annals of internal medicine 1996 May 01;124;792-802 1996 May 01
Drug-induced methaemoglobinaemia. Treatment issues.
Drug safety 1996 Jun;14;394-405 1996 Jun
Respiratory insufficiency from dapsone-induced methemoglobinemia.
AIDS (London, England) 1991 Nov;5;1392-3 1991 Nov
Methemoglobinemia provoked by malarial chemoprophylaxis in Vietnam.
The New England journal of medicine 1968 Nov 21;279;1127-31 1968 Nov 21

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