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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Dapsone (diaminophenylsulfone)

4

V.a Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

1
Last update : 08/07/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Pyrimethamine-dapsone
1

Publications

The Dapsone hypersensitivity syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations.
Journal of occupational medicine and toxicology (London, England) 2006 Jun 06;1;9 2006 Jun 06
The sulfone syndrome complicated by pancreatitis and pleural effusion in an adolescent receiving dapsone for treatment of acne vulgaris.
Journal of pediatric gastroenterology and nutrition 1998 Jan;26;103-5 1998 Jan
Non-cardiogenic pulmonary oedema associated with pyrimethamine.
Respiratory medicine 1989 May;83;247-8 1989 May

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