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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)

4

XV.bn Path: Silicone droplets/vacuoles in lung tissue, pulmonary vasculature, or lymph nodes

1
Last update : 13/02/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Silicone, fluid
5

Publications

Silicone Lymphadenopathy after Rupture of Breast Implant.
American journal of respiratory and critical care medicine 2020 Jun 01;201;e77-e78 2020 Jun 01
Chronic Pulmonary Silicone Embolism Related to Saline Breast Implants.
Annals of the American Thoracic Society 2016 Jan;13;139-41 2016 Jan
Increasing pulmonary infiltrates in a 72-year-old woman with metastatic breast cancer.
Chest 2014 Dec;146;e208-e211 2014 Dec
Pneumonitis caused by silicone gel following breast implant rupture.
Irish journal of medical science 2010 Mar;179;141-5 2010 Mar
Silicone thorax due to a ruptured breast implant.
Chest 2005 May;127;1854-7 2005 May
[Granulomatous pleurisy after mammaplasty, induced by polyacrylamide gel].
Arkhiv patologii 1998;60;58-61 1998

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