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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)

4

X.e Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

1
Last update : 13/02/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Silicone, fluid
5

Publications

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature.
Immunologic research 2017 Feb;65;120-128 2017 Feb
Silicone implant incompatibility syndrome (SIIS): a frequent cause of ASIA (Shoenfeld's syndrome).
Immunologic research 2013 Jul;56;293-8 2013 Jul
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects.
Journal of autoimmunity 2013 Dec;47;1-16 2013 Dec
Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum.
Expert review of clinical immunology 2013 Apr;9;361-73 2013 Apr
A comparison of autoantibody production in asymptomatic and symptomatic women with silicone breast implants.
The Journal of rheumatology 1999 Jan;26;73-7 1999 Jan

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