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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Apixaban

2

V.n Hemopericardium - Bloody pericardial effusion

1
Last update : 30/05/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC
3

Publications

Apixaban-Induced Spontaneous Hemorrhagic Cardiac Tamponade.
Cureus 2024 Mar;16;e55476 2024 Mar
Clinically Ambiguous Hemorrhagic Cardiac Tamponade Associated with Apixaban.
Cureus 2022 Apr;14;e24290 2022 Apr
Hemorrhagic Cardiac Tamponade Associated with Apixaban: A Case Report and Systematic Review of Literature.
Cardiovascular revascularization medicine : including molecular interventions 2019 Nov;20;15-20 2019 Nov
Spontaneous Hemorrhagic Pericardial and Pleural Effusion in a Patient Receiving Apixaban.
Cardiology research 2019 Aug;10;249-252 2019 Aug

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