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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Cytosine arabinoside - Aracytine - Cytarabine - Ara-C
3
II.b
ARDS - Acute lung injury
2
This complications likely appears to be related to the dose or Ara-C (PMID 25689584)
Last update :
19/02/2015
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Cytarabine-induced lung injury: case report.
Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia.
Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia.