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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Cytosine arabinoside - Aracytine - Cytarabine - Ara-C

3

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1
Last update : 08/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Prospective evaluation of drug-induced lung toxicity with high-resolution CT and transbronchial biopsy.
La Radiologia medica 2011 Mar;116;246-63 2011 Mar
An unusual radiologic pattern of cryptogenic organizing pneumonia: diffuse pulmonary nodules in a leukemia patient.
Korean journal of radiology 2009;10;93-6 2009
Fulminant bronchiolitis obliterans organizing pneumonia following 2 d of treatment with hydroxyurea, interferon-alpha and oral cytarabine ocfosfate for chronic myelogenous leukemia.
European journal of haematology 2004 Jul;73;67-70 2004 Jul
Bronchiolitis obliterans organizing pneumonia in three children with acute leukaemias treated with cytosine arabinoside and anthracyclines.
The European respiratory journal 1997 May;10;1187-90 1997 May

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